By Nicholas Spencer
Guy lubricates commonly with oil. Nature lubricates solely with water. natural water is a bad lubricant, however the addition of proteins, particularly glycoproteins, can adjust surfaces to lead them to way more lubricating at sluggish speeds. figuring out how nature does this, and the actual constructions concerned, isn't just vital for the certainty of illnesses equivalent to osteoarthritis, but in addition crucial for the profitable program of articulating implants, similar to hips and knees, in addition to the advance of clinical units similar to catheters and speak to lenses. a bunch of significant purposes of water-based lubrication are already in position within the own care and meals industries, and additional business purposes of water-based lubrication can have an important optimistic effect at the setting.
This booklet is the 1st of its variety. It brings jointly the newest learn in organic and biomimetic, water-based lubrication and is authored through the world's specialists within the box.
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Guy lubricates commonly with oil. Nature lubricates completely with water. natural water is a terrible lubricant, however the addition of proteins, particularly glycoproteins, can adjust surfaces to lead them to way more lubricating at gradual speeds. realizing how nature does this, and the actual buildings concerned, is not just very important for the certainty of illnesses akin to osteoarthritis, but additionally crucial for the winning software of articulating implants, akin to hips and knees, in addition to the improvement of scientific units akin to catheters and phone lenses.
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Extra resources for Aqueous Lubrication : Natural and Biomimetic Approaches
Gleghorn, A. Jones, C. Flannery, L. Bonassar, Boundary mode lubrication of articular cartilage by recombinant human lubricin. in J Orthopaed Res, Vol. 27, pp 771–777 (2009). 107. J. Gleghorn, A. Jones, C. Flannery, L. Bonassar, Alteration of articular cartilage frictional properties by transforming growth factor beta, interleukin-1 beta, and M. oncostatin Arthritis Rheum 60(2), 440–449 (2009). February 20, 2014 32 8:57 9in x 6in Aqueous Lubrication b1709-ch01 R. Crockett 108. G. E. Nugent-Derfus, A.
Weiss, Review of articular-cartilage collagen research. Arthritis Rheum 18(6), 553–562 (1975). 4. J. Jurvelin, J. Arokoski, E. Hunziker, H. Helminen, Topographical variation of the elastic properties of articular cartilage in the canine knee. J Biomech 33(6), 669–675 (2000). 5. P. Roughley, Articular cartilage and changes in arthritis — Noncollagenous proteins and proteoglycans in the extracellular matrix of cartilage. Arthritis Res 3(6), 342–347 (2001). 6. F. Cajori, R. Pemberton, The chemical composition of synovial ﬂuid in cases of joint eﬀusion.
Instead, AFM has emerged as a tool to characterize mucoadhesive interactions between mucins and polymers. J. Cleary et al. 30 A 20 µm glass microsphere modiﬁed with a layer of Pluronic-PAA copolymer was attached to the AFM cantilever to form a colloidal probe. A BSM layer was prepared by attaching a layer of mucin onto an epoxy adhesive layer deposited on a glass plate. The adhesive force is observed to be highest at pH values of 4–5, coinciding with the pKa of the carboxylic groups, and decreased at both lower and higher pH values (Fig.